Graft-versus-host can be of benefit to???

[SnowTown]

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Anyone know in what type of transplantation can graft-versus-host disease be of "some" benefit?

Bone marrow transplant for AML? Lung transplant for primary pulmonary hypertension?

 

[ENThopeful]

i THINK gvh type reaction is used in treatment for some cancers, i remember faintly from class. anyone who knows more feel free to elaborate

 

[igottaquestion]

My memory is only faint also. I want to say it's (at least some of) the leukemias. Having a small # of CD8+ cells from the graft can help kill cancer cells. I also want to say that they don't fully kill the bone marrow in the host before the transplant, as that's supposed to help. The details of which cancers and how to treat them with GVH are probably Step 2 stuff at best.

 

[stickshift]

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

 

[Depakote]

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

👍

 

[swimmy]

Here's the research. http://content.nejm.org/cgi/content/extract/350/6/614

 

[RisingSun]

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

I wonder if the same applies for autoimmune diseases - like of someone with RA or SLE sees improvement after transplant.

 

[psychforme]

I wish people would warn before they post things ripped from the nbmes

 

[Ihateverbal]

Ugh I reasoned through that question and got it right

But for some reason, I still did pretty poorly on NBME 5 and dropped from my previous NBME =(

I hope it was a fluke.

 

[neil100]

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

👍 Tip.

Simply put. I also thought of the same thing.

Plus, the lungs would not be heavily involved in graft-versus-host since it doesn't have significant population of the immune cells or lymphoid tissue. I mean there are type II penumocytes but that's really about it.


For BM, and ileum (peyer's patches) it makes much more sense.