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This was recently talked about here.
IMO
Yes, it should address your research interests, but also how you hope to couple this in being a physician(-scientist).
Perhaps address why you prefer MD-PhD training over other physician-scientist training opportunities. Perhaps avoid talking about how you only want to conduct research and never see patients, you are going through the pathway solely to avoid debt, etc.
I would say broad interests are good, but too specific interests may be frowned upon and make you appear narrow-minded. Maybe talk about disciplines that interest you, but not so much specific topics of that discipline.
IMO
Yes, it should address your research interests, but also how you hope to couple this in being a physician(-scientist).
Perhaps address why you prefer MD-PhD training over other physician-scientist training opportunities. Perhaps avoid talking about how you only want to conduct research and never see patients, you are going through the pathway solely to avoid debt, etc.
I would say broad interests are good, but too specific interests may be frowned upon and make you appear narrow-minded. Maybe talk about disciplines that interest you, but not so much specific topics of that discipline.