hi

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The citrate synthase is the rate limiting step. Isocitrate dehydrogenase is the irreversable step.
 
rate limiting step of kreb cycle is
citrate synthase
isocitrate dehydrogenase- ans

The inhibitors for this reaction are ATP and NADH
The activators is ADP
This is an irreversible step with the production of NADH and carbon dioxide
 
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