A screen by definition needs to be quick and dirty and, ideally, automated. Holistic could mean that besides MCAT and GRE they are screening in a positive manner for certain ethnicities, EO-1 and EO-2, rural (R), underserved counties (U), specific tags in your work activities section (research or clinical volunteer, or clinical employment) and even your state residence and all have it come up electronically as "if x=1 then send secondary".