Still wish I knew. My 2009 application is essentially the same as before, but with a the higher MCAT score. Yet, this time, I got interviews and acceptances at several top 25 schools. So, it must have to do something with the stats. As for the reasons this is, I dont know.
I felt that my difficulties with the admission process stemmed from not knowing "how to play the game", which sadly, can make all the difference. Unfortunately, the process has a very subjective component. As for weaknesses in my app, these are the ones that I can think of based my interview experiences at some med schools.
1)being a reapplicant and submitting my apps "relatively" later in the process
2)lack of academia based research(instead, I volunteered and worked alot)
3)Having an educational and professional background that was atypical of most premeds and apparently looked down by many medical schools(ie, dual major in business and biology, as well as working a couple years as a investment banking analyst and bond trader).
4)CA residency
5)being an overrepresented minority