How does sympathetic stimulation cause vasoDILATION?

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May 8, 2009
  1. Pre-Medical
    Smooth muscles use a different system that still involves Ca+ and actin a myosin filaments to contract. Their stimulation is due to the influx of extracellular Ca+ which bind calmodulin and activates myosin light chain kinase. The activates the myosin to contract.

    Thats how they contract.

    Sympathetic will vasodilate skeletal muscle and vasoconstrict GI smooth muscle blood vessels upon activation. The sympathetic is always responsible for some peripheral resistance (vasoconstriction) all over the body. I think upon activation if it let up its NT release then you would get vasodilation.


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    Apr 2, 2009
    1. Pre-Medical
      for constriction, sympathetic stim. releases norepinephrine which causes the smooth muscle to contract. my question is does it cause it to contract? (i think this may be beyond the scope of the mcat)

      I believe that norepi works through a GPCR pathway in which phospholipase c cleaves PIP2 into IP3 and DAG. IP3 binds onto the ER which subsequently releases Ca2+ into the cell->bind onto troponin->etc, etc... . I guess it would be assuming that the ER in this case would be interchangable with the SR though.
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