Depends on your program, IMO. If you do a lot of subspecialty signout in 1st & 2nd year, then in a way it's easier because you can focus your study more system by system. I found it difficult to maintain a regimen of reading through chapter by chapter since most texts are separated by system, when my signout was all over the place -- colon, prostate, kidney, GI biopsies, H&N, etc. etc. -- and I felt like I also needed to read up on each of those as they came up. At the end of 3-4 years it does even out. I ended up feeling more settled in reading chapter by chapter / system by system in 3rd and 4th year, but by then I had a decent grip on the common stuff we saw in our program so didn't feel the need to bop around reading about every single new case.
If I had it to do over again.. I dunno, to be honest. Most of my early plans went in the trash after a couple months, and it wasn't until much later that I felt like the world slowed down enough to read in a more organized manner and beyond what I was seeing day to day. I guess I would take the first 2-3 weeks and try to figure out what the common specimens & entities are in that program, list them out, and read about those -- personally I preferred reading about things in the same system, and closely related entities, and reading the corresponding stuff in 2 or 3 different books. The sooner you can get a good grip on the common things that you actually are seeing, the sooner you can spend time on the less common and more difficult things that may take longer to get a grip on. But every program is different and many people learn differently, so one size does not fit all.