as a florida native, the safest city from hurricanes is Jacksonville. The area north of Melbourne up to South Carolina has never been directly hit by a hurricane in recorded history*. if you look at a map, Florida juts out into the atlantic up to about Melbourne, then it cuts inward. it isn't until you get to SC that the coast starts to jut back out into the ocean and therefore be a hurricane risk again.
however.....you don't need a direct hit to suffer hurricane damage. Daytona (in that Melbourne to Jax "safe" zone) suffered a lot of damage from Hurricane Charlie (which landed on the west coast around Pounta Gorda).
so no area is technically SAFE from hurricanes in FL. but Jacksonville is the safest coastal city. other than that...the inland areas (Orlando) tend to be safer than the coasts.
I hope that helps.
*if you want to call BS on this you better tell me a hurricane name and year, i am certain that these areas have not been directly hit. the burden of proof is on the person who calls BS, not on me.