Step II Hyperprolactinoma

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zenna

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10+ Year Member
How does cocaine (dopamine reuptake inhibitor ) and Anti dpressants particularly TCA ( supposed to Increase dopamime) causes hyperprolactinoma?
 
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The increase in dopamine by cocaine blocking reuptake initially causes a suppression in prolactin secretion. However after the effects of cocaine wear off there is a drop off in dopamine levels and thus an increase in prolactin secretion as a rebound effect i.e. during withdrawal. During initial cocaine usage this rebound effect won't be that great, however the more chronic the cocaine usage the greater the rebound effect. I guess it is more accurate to say that the cocaine withdrawal is causing the prolactinemia.


Not sure about the TCA causing prolactinemia issue.
 
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