Hypersensitivity

[toothfairy2011]

---

Members do not see this ad.

Following prophylactic administration of amoxicillin, a patient becomes hypotensive and itchy and is having difficulty breathing. Which of the following is MOST probably occuring?

A. CD4 lymphocytes are secreting lymphokines resulting in edema
B. Amoxicillin reacts with IgE adn activates cytotoxic T cells to release lymphokines
C. IgG and complement are inducing the chemotaxis of neutrophils out of vessels
D. IgE bound to antigen results in histamine release from mast cells

Answer: B (Booklet 1-L, 2004)

I thought the answer was D. Does anyone know why B is right? To my understanding, IgE does not ever react with CD8 cells.

 

[aphistis]

Following prophylactic administration of amoxicillin, a patient becomes hypotensive and itchy and is having difficulty breathing. Which of the following is MOST probably occuring?

A. CD4 lymphocytes are secreting lymphokines resulting in edema
B. Amoxicillin reacts with IgE adn activates cytotoxic T cells to release lymphokines
C. IgG and complement are inducing the chemotaxis of neutrophils out of vessels
D. IgE bound to antigen results in histamine release from mast cells

Answer: B (Booklet 1-L, 2004)

I thought the answer was D. Does anyone know why B is right? To my understanding, IgE does not ever react with CD8 cells.

I would have answered D myself. Sounds like anaphylaxis, mast cell degranulation, histamine release, etc to me.

 

[quest_life]

Remember this is a type 1 hypersensitivity reaction

Following prophylactic administration of amoxicillin, a patient becomes hypotensive and itchy and is having difficulty breathing. Which of the following is MOST probably occuring?

A. CD4 lymphocytes are secreting lymphokines resulting in edema
B. Amoxicillin reacts with IgE adn activates cytotoxic T cells to release lymphokines
C. IgG and complement are inducing the chemotaxis of neutrophils out of vessels
D. IgE bound to antigen results in histamine release from mast cells

Answer: B (Booklet 1-L, 2004)

I thought the answer was D. Does anyone know why B is right? To my understanding, IgE does not ever react with CD8 cells.

 

[toothfairy2011]

Yes, I definitely agree that this is a type I hypersensitivity reaction.

My recollection is that type I hypersensitivities don't involve CD8, which is what B seems to suggest. Mostly, they involve mast cells and occasionally, CD4 can be involved.

Is there something I am overlooking?

 

[DancingKoala]

Do we still not have correct explanation for this?
And what indicates that this is hypersensitivity type 1? I am still trying to learn about different types and their key words.