I will <3 you forever if you get this right...

[NJDental]

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predict the secondary structure of

-thr-phe-gly-lys-thr-val-tyr-glu-gly-leu-gly-asn-pro-

and

-ser-val-gly-glu-ser-phe-tyr-arg-leu-gly-asn-pro

😕

 

[Lopyswine]

biochem isn't too bad....

just look at the pka and you should get an idea

 

[armorshell]

Beta pleated sheet. Why else would the give you two strands?

 

[armorshell]

biochem isn't too bad....

just look at the pka and you should get an idea

lol whut?

 

[NJDental]

yea i figured beta sheets, i just am having difficulty drawing that up

pKa?? this is for physio not chem but thank you anyway 😉

 

[scottyhoop]

i thought it was a biochem issue as well. We did stuff like that in biochem non-stop, but for the life of me I can't remember it! haha...looks like I'll have to dig out my notes and check it out. Please let me know if Beta sheet is correct, but I'm going to check on it tmw just for fun...good luck!
Scott

 

[armorshell]

yea i figured beta sheets, i just am having difficulty drawing that up

pKa?? this is for physio not chem but thank you anyway 😉

Remember that secondary structure is derived from h-bonding interactions of the protein backbone only, so don't be led astray by the sidechains. For the most part, in a beta pleated sheet, they don't matter.

 

[dr bojangles]

beta sheets.
your pro/gly's are alpha helix breakers, only found in turns. you got a bunch of bulky aromatics (phe, thr, tyr), which prefer beta chains.
biochem/mol bio major here, and masters now......took that almost 4 yrs ago, and my brain still hurts.
when do i get to start d-school?

 

[UCSF2012]

I guess you could locate the potential sites for H-bonding and try to pair up the sequences against each other. I guess you could also try to determine whether they're in parallel or antiparallel arrangement. That sounds way too complicated a problem, so if I were you, I'd just get that question wrong and focus on the other questions. Hope that helps.🙂

 

[NJDental]

beta sheets.
your pro/gly's are alpha helix breakers, only found in turns. you got a bunch of bulky aromatics (phe, thr, tyr), which prefer beta chains.
biochem/mol bio major here, and masters now......took that almost 4 yrs ago, and my brain still hurts.
when do i get to start d-school?

thanks - wow 4 years, props to you!

 

[NJDental]

I guess you could locate the potential sites for H-bonding and try to pair up the sequences against each other. I guess you could also try to determine whether they're in parallel or antiparallel arrangement. That sounds way too complicated a problem, so if I were you, I'd just get that question wrong and focus on the other questions. Hope that helps.🙂

haha yea, i would like to get it right tho because i did just that on 4 others....so i dont want to make it 5.

its midnight im about ready for bed....one more problem to go!

 

[NJDental]

i thought it was a biochem issue as well. We did stuff like that in biochem non-stop, but for the life of me I can't remember it! haha...looks like I'll have to dig out my notes and check it out. Please let me know if Beta sheet is correct, but I'm going to check on it tmw just for fun...good luck!
Scott

thank you!! let me know watcha find lol

 

[sajjy]

predict the secondary structure of

-thr-phe-gly-lys-thr-val-tyr-glu-gly-leu-gly-asn-pro-

and

-ser-val-gly-glu-ser-phe-tyr-arg-leu-gly-asn-pro

😕

"I will <3 you forever if you get this right..."

just for this line i am going to ask a biochem professor tomorrow morning.....and since we might be rooming together at Gateway to Dentistry.....I GOTTA GET IT😉😀😀

 

[TheWiredNerv]

beta sheets.
your pro/gly's are alpha helix breakers, only found in turns. you got a bunch of bulky aromatics (phe, thr, tyr), which prefer beta chains.
biochem/mol bio major here, and masters now......took that almost 4 yrs ago, and my brain still hurts.
when do i get to start d-school?

What he said. Pro and gly are found in linker regions of the beta sheets. Now is it parallel or anti-parallel 😀?

 

[jeezy]

i cant believe i found this. its called the chou-fasman rules and thats how i learned to predict

http://www.image-upload.net/files/9772/chou%20fasman copy.jpg

 

[UCSF2012]

i cant believe i found this. its called the chou-fasman rules and thats how i learned to predict

http://www.image-upload.net/files/9772/chou fasman copy.jpg

Well, this is one of the major algorithms used to predict protein structure. It may or may not apply, depending on what the question's really asking. The algorithm's used by inserting a protein sequence, and it'll spit back out a prediction. However, this question MAY ask about the interaction of 2 sequences, in which case it doesn't apply (or it's 2 separate sequences to be analyzed separately, in which case it'll apply).

 

[armorshell]

You guys are getting way too advanced for what this question is asking. Just draw out the beta sheet h-bond interactions between the backbone of the two structures and call it a night.

 

[UCSF2012]

You guys are getting way too advanced for what this question is asking. Just draw out the beta sheet h-bond interactions between the backbone of the two structures and call it a night.

One step ahead of ya. I woulda left the question black and gone to sleep.😴

 

[tinman831]

Moving to DAT.

 

[phraud]

The answer is C. You're welcome. 😀

 

[NJDental]

"I will <3 you forever if you get this right..."

just for this line i am going to ask a biochem professor tomorrow morning.....and since we might be rooming together at Gateway to Dentistry.....I GOTTA GET IT😉😀😀

hahaha im waiiiiiiiiiitingggg 😉

 

[NJDental]

sorry saj....

i can't show you any love now 🙁😳

haha

 

[sajjy]

sorry saj....

i can't show you any love now 🙁😳

haha

🙁🙁🙁...i am a living example who shows that exams and studies can ruin any situation......i got busy with series of exams...🙁🙁
no worries..i still have Gateway to get that love back😍😀

 

[NJDental]

🙁🙁🙁...i am a living example who shows that exams and studies can ruin any situation......i got busy with series of exams...🙁🙁
no worries..i still have Gateway to get that love back😍😀

its ok...exams are important, ive got orgo exam tomorrow 8am which is in approx 9.5 hrs so im going to go study too.....

i really hope i get into gateway! we find out sooooon!!! 😀

 

[sajjy]

its ok...exams are important, ive got orgo exam tomorrow 8am which is in approx 9.5 hrs so im going to go study too.....

i really hope i get into gateway! we find out sooooon!!! 😀

yah....but u have only orgo.....i am actually practicing the life at dental school right here in undergrad.....
i had geog exam today......two exams -material science and orgo lab exam tomorrow and a lab report due........one exam on biomaterials and a lab report on thursday and then another lab report due friday.....
JUST KILL ME!!!

 

[utmed07]

I second mr. Bojangles, "P" and "G" are helix breakers. P lacks an amide hydrogen to donate for hydrogen bonding, and G is conformationally unstable. However, its not uncommon to find "P" at the beginning of a helix ( helix capping).

 

[edmilla3]

Beta sheets, phe doesn't do well with alpha helices

 

[lilsnoboardr22]

beta pleated sheets, the proline in the primary structure does not allow alpha helices becuase of its circular structure.