Immunogenetics

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devriyeL

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Its my first year as a MS and my classes hasn't even started yet. But I was curious enough to search for things and I found out Immunogenetics. Could someone inform me about Immunogenetics because I think this branch could help our future so much. What do they do , what are they trying to accomplish ?
 
Age and inflammation go hand in hand through SASP, CD38 expression and depletion of cellular NAD pools. You figure out what to do about senescence, and you win a Nobel prize in medicine.

Probably a swing and a miss on my part on what actually constitutes as “immunogenetics”, but I’m fascinated by epigenetic changes that occur over our lifetimes.
 
devriyeL said:
Its my first year as a MS and my classes hasn't even started yet. But I was curious enough to search for things and I found out Immunogenetics. Could someone inform me about Immunogenetics because I think this branch could help our future so much. What do they do , what are they trying to accomplish ?
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One has to master the google search function if one going to survive medical school.

It tool me all of five seconds to find these:







 
devriyeL said:
Its my first year as a MS and my classes hasn't even started yet. But I was curious enough to search for things and I found out Immunogenetics. Could someone inform me about Immunogenetics because I think this branch could help our future so much. What do they do , what are they trying to accomplish ?
Click to expand...

Hi!
One can do clinical immunogenetics through 2 subspecialties: medical genetics and allergy/immunology.
Immunogenetics deals with finding (through sequencing) genes and pathways not yet identified (or identified already) that impact the functioning of the immune system.
Usually this involves cases where the patient has a “mystery” disease—aka no regular lab test to confirm diagnosis, and likely abnormal immune panels (immunoglobulins, percentages of T/B/NK cell populations, or abnormal lymphocyte proliferation studies, among others). This can be clinically accompanied by either hyperinflammation or immunodeficiency (or both, most commonly).

Immunogenetics is an amazing field of discovery. With whole exome sequencing becoming so cheap it has been a revolution in the realm of immunodeficiencies, with many insights showing for example that many “deficiencies” are actually problems of immune dysregulation, and absence of one part of the immune system leads to autoimmunity, or inflammatory diseases that present in the same patient.

I am biased (AI-bound), but it is truly one of the last areas in Medicine where you still play a bit of the role of Dr House, and where uptodate won’t be very helpful (though NOMID, ImmGen, and other similar projects will).
 
biobukowski said:
Hi!
One can do clinical immunogenetics through 2 subspecialties: medical genetics and allergy/immunology.
Immunogenetics deals with finding (through sequencing) genes and pathways not yet identified (or identified already) that impact the functioning of the immune system.
Usually this involves cases where the patient has a “mystery” disease—aka no regular lab test to confirm diagnosis, and likely abnormal immune panels (immunoglobulins, percentages of T/B/NK cell populations, or abnormal lymphocyte proliferation studies, among others). This can be clinically accompanied by either hyperinflammation or immunodeficiency (or both, most commonly).

Immunogenetics is an amazing field of discovery. With whole exome sequencing becoming so cheap it has been a revolution in the realm of immunodeficiencies, with many insights showing for example that many “deficiencies” are actually problems of immune dysregulation, and absence of one part of the immune system leads to autoimmunity, or inflammatory diseases that present in the same patient.

I am biased (AI-bound), but it is truly one of the last areas in Medicine where you still play a bit of the role of Dr House, and where uptodate won’t be very helpful (though NOMID, ImmGen, and other similar projects will).
Click to expand...

I should also say, the videos posted talk about the classic (bread and butter) HLA matching done with transplants, but that is not what immunogenetics means to an immunologist. We already know of histocompatibility and antibody variable regions. The field is concerned with genetic defects in general causing immune problems. Defects which were previously ignored or not known since we could not sequence every patient.

But I want to plug A&I again, and say that if what interests you is the transplant immunology part, it is really beautiful field, and worth your consideration if you want to come up with the discoveries that will save transplants in the years to come!
 
biobukowski said:
I should also say, the videos posted talk about the classic (bread and butter) HLA matching done with transplants, but that is not what immunogenetics means to an immunologist. We already know of histocompatibility and antibody variable regions. The field is concerned with genetic defects in general causing immune problems. Defects which were previously ignored or not known since we could not sequence every patient.

But I want to plug A&I again, and say that if what interests you is the transplant immunology part, it is really beautiful field, and worth your consideration if you want to come up with the discoveries that will save transplants in the years to come!
Click to expand...
Thank you so much for the information! I appreciate it
 
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