I did a rotation at an independent pharmacy a few months ago and the most interesting part about it was its location. It was on the same corner as a walgreens and cvs. Granted it was a very busy intersection but I thought this was a pretty ballsy move by the owner. From what I could tell his business was thriving too. The key, according to him, was to work for a major chain, become a pharmacy manager and then open one. He actually opened it across from the cvs he had managed and took many of his customers with him.