inflammatory response

[astronaut135]

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I'm confused about where inflammatory response (or innate immunity in general) happens:

Does it take place in the lymphatic system or in the tissues/interstitial fluid?

During inflammation when blood capillaries dilate and let out leukocytes, do the leukocytes go to the lymph or the tissue?

And is the swelling due to the enlargement of lymph nodes or due to the accumulation of leukocytes in the tissues? Do they mean the same thing?

Thanks in advance!

 

[Helixkam]

I think the swelling is due to factors that are released from damaged cells. The inflammation constricts lymph and other fluids in the area and causes fluid buildup. The reasoning for this is to keep all the harmful stuff isolated. The enlargement of lymph node happens i think when bad stuff enters the lymphatic system and is filtered through particularly the spleen. This is the way I learned it but im not 100% on it