Infusion Calculation please I need a hand....

[1last]

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A pharmacist places 5mg/ml of acyclovir sodium in 250ml of D5W for parenteral infusion into a pediatric patient. If the infusion is to run for 1 hour and the patient is to receive 500mg/m2 BSA, what would be the rate of flow in milliliters per minute for a patient measuring 55cm in height and weighing 10kg?
Answer: 0.58ml/min
I tried to calculate multiple times but I just couldn't get the right answer.
My calculated BSA is 195 mg..
Somebody can help me how to come up with the answer....I will appreciate it...
By the way, this practice problem is from Stoklosa's book.

 

[Pharmamomma]

You need to know how many ml of acyclovir was placed in 250 ml to get the concentration per ml.

 

[1last]

You are absolutely right. But my answer is 0.65ml/min.

 

[xtsukiyox]

I'll take a stab...

I get the same thing as you (approx 39mL of 5mg/mL solution needed, which works out to 0.65mL/min if infused over 1 hour). My BSA is about 0.390 m^2 using the Mosteller formula.

Reverse-engineering their answer, 0.58mg/mL = 34.8mL delivered = 174 mg dose = 0.348 m^2 BSA

I wonder if they're using a different BSA formula or something?

 

[triumf]

BSA using Dubios and Dubios equatio:

0.007184 X wgt(kg)^0.425 X Hgt(cm)^0.725

The patient's BSA will be 0.3492 which gives a dose of 174.58mg approximately 34.91ml.

The infusion rate is 0.58ml/min

 

[1last]

Ouch!!There's no way I will get the answer as I applied different formula that I know..Yes I heard Dubios equation but never tried it...well I guess memorizing all the possible formulas is a good idea. Never thought Stoklosa would going to use it though.
You guys are awesome!!!
Thank you so much for helping me out...