Insulin and C-peptide

[Step1Hash]

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Does anyone know where and how C-peptide gets cleaved off of insulin?

FA doesnt even mention it and UWORLD has 2 different explanations:
One says it gets cleaved in the Golgi via convertases and the other says it gets cleaved in the ER by endopeptidases.

 

[ArcGurren]

There's a number of proteolytic enzymes which are involved in insulin cleavage. I'm pretty sure if they ever ask that kind of question it'll be more or less clear. I've never read a single source that gives something definitively on the identity of that particular enzyme.

 

[Step1Hash]

Sounds good, thanks

 

[engineeredout]

The reason that Protease inhibitors cause hyperglycemia is because they prevent the cleaving of the C-peptide from the insulin molecule, decreasing the insulin release. So it would seem a peptidase is important.

 

[Step1Hash]

sweet, thanks engineer...now I wont forget that

 

[ArcGurren]

The reason that Protease inhibitors cause hyperglycemia is because they prevent the cleaving of the C-peptide from the insulin molecule, decreasing the insulin release. So it would seem a peptidase is important.

Good catch mate - lipodystrophy and hyperglycemia makes more sense now!

 

[engineeredout]

Good catch mate - lipodystrophy and hyperglycemia makes more sense now!

sweet, thanks engineer...now I wont forget that

Thank Lionel Raymon. That man is a genius. And yeah, explaining why side effects actually happen helps you to remember them so much better than just trying to cram in one more random fact after two years of random facts.