Interesting Iatrogenic Complication

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Shodddy18

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Had an interesting patient last night… something I had not run into before. I'm wondering if any of you have seen this.

25 year old female presents with chest pain, syncope and vomiting blood. Vitals and physical are essentially normal. She reports a history of Barrets esophagus and nissen fundoplication. She has very poor peripheral veins due to numerous recent iv sticks. Eventually I place a right EJ. Goes in smoothly, good blood return. I'm able to draw all the labs for the nurse off of this. It is hooked up to saline and is flowing. The patient later describes some discomfort in that area. I recheck the iv, still has good blood return and no evidence of infiltration. Chest X-ray is normal except for a subtle abnormality… density along right mediastinum. No pneumothorax. Time goes by, labs are normal. Guiac negative, NG lavage negative. Pt's pain is getting worse. Skipping many of the details, eventually order a CT angio of the chest to evaluate for PE. I then get a call from the CT tech that all of the contrast had extravasated into the patients neck. The CT was continued with out contrast. It shows that there is mass effect from the contrast causing some mild shift of trachea and mediastinum but not major. It also shows that there is a large right pleural effusion.

The X-ray had not shown this an hour or so before. When I saw the pleural effusion… i nearly lost all sphincter tone… initially thinking that I somehow caused an arterial puncture and that this was a hemothorax. The patient remained hemodynamically stable. The density of the fluid was likely transudative per radiologist. The patients H/H remained stable.

It now seems obvious that he abnormality in the mediastinum was likely from fluid extravasating from the line early on… although it seemed to be working fine and there was no physical evidence of infiltration. The large pleural effusion was likely the 1 liter normal saline bolus I had ordered for my patient.

I discussed the case with vascular, mostly regarding the shifting of the mediastinum due to contrast extravasation. They didn't seem to think it would be a problem at all and didn't seem to impressed. He said he had seen similar things before. They recommended serial h/h and repeat X-ray in the morning but expect that since she is otherwise healthy the pleural fluid will reabsorb without a problem.

Now the worst part is that after I was scratching my head from working this lady up for an upper gi bleed and finding no evidence of one, I received an "anonymous" phone call from a concerned friend/family member telling me that she has been to 4 other hospitals recently with her complaints of vomiting blood and chest pain. She was eventually discharged from all of them with a diagnosis of psychiatric illness.

At this point I had to call the hospitalist with my tail between my legs so that they could admit this patient, not for her chief complaint, but for her iatrogenic pleural effusion and extravasated contrast.

Have any of you ever seen an EJ infiltrate like this??? Local infiltration I can understand but she didn't demonstrate that. All of the fluid seemed to go into the pleural space. This was a pretty easy superficial stick so I can't imagine the catheter was in the pleural space directly. It must have dissected through the tissues and collected there.

Strange...
 
The rads guys at two of my shops actually refuse to push contrast through EJs citing "airway compromise" if the contrast extravasates. Never seen it happen and it always sounded a bit bogus.

Kinda interesting that even with contrast and a liter of fluid there were only non-significant airway changes.

Thanks for sharing this case!
 
Our health system (350,000 ED patients/year) does not allow contrast to be pushed through an EJ. If the patient needs contrast and the nurse/IV team/you can't get a peripheral IV, then you put in a central line.

If the patient needs to be admitted and the nurse/IV team (who use ultrasound) cannot get an IV, then I just put in a central line. Allows for blood to be checked easily and has more reliable access. I've yet to have a CLABSI because I wash my hands prior to the procedure and practice good sterile technique.
 
We do not have that policy at my shop. Initially it seemed as thought it was an upper GI bleed as the patient seemed to know what she was talking about. I just wanted quick access… nurses couldn't get either arm so I through in a 16 gauge EJ. It wasn't until rectal turned out negative and gastric lavage was negative that I began to think about a PE. When it came time for the CT, I had access and didn't think twice about using it.

As an update, she is doing fine. Contrast cleared from her neck within 12 hours. Effusion resolving. I was nervous though.

I will never put contrast through an EJ again…

Although I'm still curious about the pleural effusion. Im surprised that much fluid would find its way to collect in the pleural space without any outward evidence of infiltration. Even after I saw the mass effect in her neck on the CT I swear no one could see any evidence of this externally. Structures all felt normal with palpation as well.

We live and we learn.

Cheers!
 
Agree with the above posters regarding no contrast via EJ, especially you're doing a PE study which requires a rapid infusion. Even with a central line, it has to be a powered central line (not regular TLC) to account for the rate of infusion.

Given that it wasn't a local infiltration, it was unlikely that your EJ was bad or went SubQ ect. More than likely, somewhere distal to your site, the vascular structure busted due to the pressure from infusion. I think if you had ran the CT through the neck too, you might have see the trail of your contrast and localize the site. They can probably still do the CT-neck on the floor as the contrast is sitting extravascularly with a much slower rate of absorption.

Please keep us updated! sounds like your vascular guys aren't impressed, that's a good sign 🙂
 
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