Irreversible inhibition vs noncompetitive inhibition

[akimhaneul]

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Is irreversible inhibition a lot more permanent than noncompetitive inhibition? They sound very similar except that kaplan says irreversible inhibition requires synthesis of new enzymes.

 

[rabbott1971]

Irreversible inhibition involves covalent bonding between the enzyme and the inhibitor.
Reversible inhibitors bind non-covalently. Competitive, non-competitive, and un-competitive inhibitors are all reversible.