IVH

[aspiringmd1015]

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intraventricular hemorrhage seen in ARDS, it occurs due to the germinal matrix malfromation. So giving high dose 02 causes IVH how? free radical production and damage of the germinal matrix?

 

[worldbeater]

I thought this was related to Vitamin K deficiency? Lack of clotting factors, home birth, etc..

 

[aspiringmd1015]

no, thats Intracranial hemorrhage. Intraventricular hemorrhage is with supplying 02 to a neonate who's hypoxemic like in ARDS. germinal matrix malformations

 

[dorster]

Well I think its b/c the premature ventricular system aka germinal matrix is weak and very vulnerable to hypoxic ischemic damage. So when the baby has NRDS and the weak vessels become ischemic, the walls become damaged and friable. So when you all of a sudden add in high dose oxygen the damaged vessels are overwhelmed kind of like reperfussion injury in the heart which leads to hemorrhage of the vessels. Im assuming theres probably also ROS production which further damages the endothelium again like reperfussion injury.