kaplan pharmac lecture notes antianginal figure error

[tarsuc]

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I just noticed this blatant error in Kaplan lecture notes in the anti anginal drugs chapter.

If you take figure III-5-2 (Mechanisms of smooth muscle contraction and relaxation and drugs affecting them) (2010 version of notes)

In bottom left corner of the figure, they have shown that bradykinin, H1, M3 act via Gq coupled receptors, which then increase NO leading to activation of guanyl cyclase.

But doesnt Gq receptors act via PIP2 system (IP3, DAG).

So isnt this wrong? Or am i wrong?

Then by what molecular mechanism does m3,h1 and bradykinin cause relaxation of smooth muscle?

 

[PiBond]

I just noticed this blatant error in Kaplan lecture notes in the anti anginal drugs chapter.

If you take figure III-5-2 (Mechanisms of smooth muscle contraction and relaxation and drugs affecting them) (2010 version of notes)

In bottom left corner of the figure, they have shown that bradykinin, H1, M3 act via Gq coupled receptors, which then increase NO leading to activation of guanyl cyclase.

But doesnt Gq receptors act via PIP2 system (IP3, DAG).

So isnt this wrong? Or am i wrong?

Then by what molecular mechanism does m3,h1 and bradykinin cause relaxation of smooth muscle?

I don't have Kaplan's lecture notes but they are correct to my knowledge.

Bradykinin is coupled to Kq which results in increased intracellular Ca2+. This Ca2+ will complex with calmodulin and activate endothelial NOS (eNOS). eNOS will produce its nitric oxide that diffuses in to the smooth muscle cell and cause relaxation.

 

[tarsuc]

thanks a lot for replying.

Does the same apply for m3, H1?

I thought they acted through Gq receptors.