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what is the route of spread hematogenous or seeding ?
krukenberg's tumor
- Thread starter Ycut
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Hematogenous as per Goljan!!! He explained it that if it was seeding, the signet ring cells should be seen all over the place rather than a specific place around the overies... so he says it's hematogenous.
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yeah, that's right
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it's not logical. there's actually some debate on this subject:
"There is some debate over the exact mechanism of metastasis of the tumor cells from the stomach, appendix or colon to the ovaries. Classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but recently some researchers have suggested that lymphatic (i.e. retrograde through the lymph nodes), or hematogenous (i.e. through the blood) spread is more likely, as most of these tumors are found inside the ovaries. Proponents of this theory cite the fact that metastases are never found in the omentum and that the tumor cells are found within the ovary and not growing inward. [1]
source: http://www.ijpmonline.org/article.a...53;issue=4;spage=874;epage=875;aulast=Khurana
also;
"Several mechanism have been suggested to explain the progression and recurrence pathway of gastric cancer such as lymphatic spread, hematogenous spread, direct invasion, peritoneal seeding, etc. Among them, the incidence of hematogenous recurrence is highest. Although Krukenberg tumor also may be induced by complex mechanisms, as a factor for metastasis, lymph node metastasis is considered to be the most potent risk factor for recurrence.(11,12) "
source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204473/
