Lack of ketones in CF patients in DKA

[Pinkleton]

---

Members do not see this ad.

Hey guys, does anyone know why cystic fibrosis patients with type 1 diabetes are usually unable to form ketone bodies?

 

[Pinkleton]

Nobody??

 

[Instatewaiter]

If they don't make ketones, then they are not in DKA. You need three things to be in DKA
1) Diabetes
2) Ketones
3) Acidosis

For the most part, CF patients make enough insulin not to form ketones. When someone with CF has DKA you should screen them for insulin/GAD antibodies.