Leishmaniasis

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Black usually means a necrotic process is occurring. So I'd guess necrosis.

But the three main types of leishmaniasis (cutaneous, mucocutaneous, visceral) all tend to initially present with a skin lesion, as the sandfly bite is what transmits the protozoa.
 
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It's because in visceral leshmaniasis the amastigotes of the parasite infect the macrophages. And subsequently,,the immune response relies on the activation of the macrophages thru various inflammatory cytokines((inf,,IL12)) to control de infection within them,,increased cytokines disrupts hypothal-pit-adrenal axis wit incresd CRH & incresd ACTH,,incresd MSH as part of the byproduct of POMC,,nd that wud lead to hyperpigmentation,,
 
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TheNsg300 said:
It's because in visceral leshmaniasis the amastigotes of the parasite infect the macrophages. And subsequently,,the immune response relies on the activation of the macrophages thru various inflammatory cytokines((inf,,IL12)) to control de infection within them,,increased cytokines disrupts hypothal-pit-adrenal axis wit incresd CRH & incresd ACTH,,incresd MSH as part of the byproduct of POMC,,nd that wud lead to hyperpigmentation,,
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Wow i never thought about it that way, nor did i know that increased cytokines causes a disruption in that axis. Thanks
 
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TheNsg300 said:
It's because in visceral leshmaniasis the amastigotes of the parasite infect the macrophages. And subsequently,,the immune response relies on the activation of the macrophages thru various inflammatory cytokines((inf,,IL12)) to control de infection within them,,increased cytokines disrupts hypothal-pit-adrenal axis wit incresd CRH & incresd ACTH,,incresd MSH as part of the byproduct of POMC,,nd that wud lead to hyperpigmentation,,
Click to expand...
so you mean in any inflamation everything will be black due to cytokines? What about TB?
 
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Khorreed said:
so you mean in any inflamation everything will be black due to cytokines? What about TB?
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Well u cud see it this way,,in MTB the macrophages/RES aren't the primary target,,the macrophages jus seem to phagocytose a pathogen that they can't breakdown,,nd de level of the inflammatory response iz reduced wen compared wit visceral leshmaniasis which primarily targets de RES nd macrophages,,with subsequent increased macrophage destrn,,activation nd in severe cases pancytopenia with massive hepatospleenomegaly,,which again isn't typical for TB,,
 
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