Excessive note taking and annotating of first aid is counterproductive, towards the end, seeing all those notes, in the margins is quite annoying. I also wasted time, annotating and writing things and trying to learn things perfectly the first time, well I think for the USMLE, reviewing is key, because by the time you cover all of Micro and Immuno for one week, the embyo you studied 2 weeks ago is not as fresh in your mind. So rather than spending so much time on each subject, I wish I had reviewed them multipe times instead.