- Joined
- Nov 26, 2013
- Messages
- 1,352
- Reaction score
- 193
1. So Kaplan pharm says lidocaine will decrease action potential duration (APD), so won't that increase the HR though?
For example, class III such as amiodarone does increase APD, which slowers HR as an antiarrhythmic drug (which slowers HR) right?
Or does APD have nothing to do with HR?
2. Can anyone explain the rationale using lidocaine for digoxin toxicity?
Lidocaine basically blocks the inactivated sodium channel and digoxin inhibits Na/K ATPAase which seems to be irrelevant to how lidocaine works, can anyone enlighten me?
Many thanks in advance.
For example, class III such as amiodarone does increase APD, which slowers HR as an antiarrhythmic drug (which slowers HR) right?
Or does APD have nothing to do with HR?
2. Can anyone explain the rationale using lidocaine for digoxin toxicity?
Lidocaine basically blocks the inactivated sodium channel and digoxin inhibits Na/K ATPAase which seems to be irrelevant to how lidocaine works, can anyone enlighten me?
Many thanks in advance.
Last edited: