Lipogenesis

[speedypillz]

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My first post after ~2 years of lurking around on this site as a guest- please go easy on me senpais. 🙂

I ask because there seems to be no clear cut information on this available upon googling.
Some say slightly differently from others so I wanted to clarify for myself once and for all.

I understand lipogenesis means a "genesis" of lipid from "acetyl-CoA"

Since, acetyl-CoA can be generated from various intermediates or products of other metabolism pathways, the above statement could be rephrased as:

Lipogenesis is synthesis of lipid from glucose/ and other intermediates (via glycolysis) and perhaps lipid itself (since lipids can produce acetyl-CoA via beta-oxidation).

But since to say that lipogenesis is synthesis of lipid from lipid is somewhat opposing to itself, I assume more refined definition would be:

lipogenesis is synthesis of lipid from non-lipid substrates that generate acetyl-CoA (just like gluconeogenesis is synthesis of glucose from non-carbohydrate substrate)

Is this right?

Also, I stated that the product of lipogenesis is lipid (instead of fatty acids or triglycerides) because I wanted an answer on this part as well.

So roughly speaking, I know that acetyl-CoA -(process A) --> fatty acids --(process B)--> triglyceride.

But is lipogenesis only specific to process A? (meaning, acetyl-CoA turn to fatty acids and fatty acids turn into tryglycerides naturally by another process with its own term)

Or should process B included as part of lipogenesis as well.

I get really OCD when it comes to these kind of things that it distracts me if I try to move on to study other things.

Thank you!

 

[DetroitDoc1993]

I think you are worrying about this a little too much seems but let me try to help and clarify.

Lipogenesis is the synthesis of fatty acids from either glucose/carbs or none glucose sources for carbons. Tryglycerides are simply esterified fatty acids using glycerol so both of these processes are lipogenesis it encompasses both processes.

So when a certain physiological response is to increase lipogensis (like in a high carb diet or when stimulated by insulin) then that causes fatty acid synthesis and triglyceride synthesis and then storage in adipocytes. You should also keep in mind that lipogenesis is very closely related to cholesterol synthesis; simplifying it to state that when you are in a physiological state of lipogenesis, you will be synthesizing not only fatty acids and triglycerides, but also cholesterol and this has physiologic and biochemical dependence and plays roles in diseases like obesity and type 2 diabetes.