Lithium deficiency in MCI and Alzheimer's

[thelastpsych]

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A recent article on Nature explored the relationship between Lithium deficiency in some cortical regions, and mild cognitive impairment/ alzheimer's: "Reducing endogenous cortical Li by approximately 50% markedly increased the deposition of amyloid-β and the accumulation of phospho-tau, and led to pro-inflammatory microglial activation, the loss of synapses, axons and myelin, and accelerated cognitive decline"

I was wondering if you guys tend to use lithium more on bipolar patients with MCI/AD or as first line as an augmentation strategy for unipolar depression in these patients, since the antipsychotics tend to worsen cognition overall (except maybe lurasidone?).


Reference: Lithium deficiency and the onset of Alzheimer's disease - PubMed

 

[comp1]

Omph, that is not a pill you want to want to mess around with "Did I take my dose already?"