There have been a few mentions by people in the field that we're reaching dead-ends, woe is us.
All fields of medicine, in science reach dead ends all the time but doors open too. I don't see why those people thinking our field hit a wall feel this way except that maybe they're getting a little too complacent/stagnant in their belief that everything can be explained using old and crude methods to gauge psychiatry.
If you think our entire field is defined by the use of SSRIs and when we've reached the point where companies don't want to research any more SSRIs because there's enough $4 ones so where's the profit,.......I think you get the point.
We've always known that dopamine doesn't fully explain psychosis, 5HT, DA, and NE are not the end-all-be all with depression, that we have a THC receptor but haven't reliably identified what role it's supposed to play in our brain (I don't mean by using cannabis, why is it there in the first place), there's dozens of chemicals in the brain we've identified but don't know what they do.....
So when I hear some doctors mention woe is us because pharm companies don't want to do much more research on SSRIs, I politely ask them why they are allowing SSRIs to define their opinion of our profession. We're psychiatrists, not brand-new $400/month SSRI salesmen.