Step I mannose 6 phosphate?

[MoscowAbe]

Is it in the RER or golgi that it targets protiens. In FA it says Golgi but in DIT he says RER?😕

 

[PokerDoc]

Hmm i didnt catch him say that, prob cuz I wasnt paying as much attention in areas I didn't want to listen to

But it occurs in the cis-golgi

i know because I got a dick question once that asked me to chose between cis and trans golgi among others and im like WTF!!!!!

 

[engineeredout]

From Ross histology:

"Hydrolases are synthesized in the rER as ezymatically inactive precursors callsed prohydrolases... The signal patch on a protein destined for a lysosome is then modified by several enzymes that attach M6P... M6P REceptors are present in early and late endosomes, lysosomes, and the golgi apparatus, whic is involved in sorting and retrieving secreted prohydrolases destined for transport to endosomes".

I think for all intents and purposes its golgi, and when the Golgi can't attach the M6P you get I-cell disease.

 

[MoscowAbe]

Thanks to both of you 🙂

 

[Vikingwizardguy]

to add: Uworld says golgi. got that question wrong the other day, won't get it wrong on the real thing lol.

 

[DrVanNostran]

to add: Uworld says golgi. got that question wrong the other day, won't get it wrong on the real thing lol.

I-cell disease and CF seem to be board favorites. I had almost identical world questions appear on the real deal about both.

 

[MilkmanAl]

Yeah, that's one of the few things I actually remember from cell bio. It's Golgi.