MEN2A

[marshmanic]

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Pg. 560 of First Aid describes how RET oncogene mutations can lead to neural crest tumors, i.e. pheochromocytoma, medullary carcinoma of the thyroid and (the part that confuses me) parathyroid adenoma.

I get the first two -- pheochromocytoma and adenoma of the parafollicular cells -- these are neural crest derivatives.

But what is the deal with parathyroid adenoma? Isn't it an endodermal derivative?

Thx!
Dan

 

[Transposony]

It also has contributions from ectoderm and neural crest .
Also AFAIK it is parathyroid hyperplasia and not adenoma.

 

[ChessMaster3000]

It also has contributions from ectoderm and neural crest .
Also AFAIK it is parathyroid hyperplasia and not adenoma.

correct, Uptodate describes it as "multigland parathyroid hyperplasia" (good call!)