micro/path quetsion

[sania]

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can u guys explain this...


the pulmonary neoplasm to which the endocrine effect of parathyroidism is attributed is
1)adenocarcinoma
2)oat cell carcinoma
3)pheochromocytoma
4)medullary carcinooma
5)squamous cell carcinoma

Ans is 2..i though oat cell carcinoma only produces ADH and ACTH..anyone knows link with parathryorid.

thanks!!

 

[gbasyildiz]

5

 

[ibeflossin]

can u guys explain this...


the pulmonary neoplasm to which the endocrine effect of parathyroidism is attributed is
1)adenocarcinoma
2)oat cell carcinoma
3)pheochromocytoma
4)medullary carcinooma
5)squamous cell carcinoma

Ans is 2..i though oat cell carcinoma only produces ADH and ACTH..anyone knows link with parathryorid.

thanks!!

Oat cell simply means "small cell". It is thought to originate from neuroendocrine calls (APUD cells) in the bronchus called Feyrter cells. They express varieties of neuroendocrine marks & may lead to ectopic production of hormones like ADH & ACTH that may result in paraneoplastic syndromes, & SIADH.

Oat cell carcinoma: Kulchitsky (APUD) cell of origin, tiny white, fishflesh primaries near hilum with early and widespread metastases; 15 micron almost-no-cytoplasm cells, paraneoplastic syndromes include, Eaton-Lambert, inappropriate ADH, Cushingism from ACTH, more; not hypercalcemia. Bombesin's the autocrine growth factor. Remember secondary hyperparathyroidism is commonly caused by hypercalcemia!

Squamous cell carcinoma: Keratin pearls, bridges (prickles, desmosomes), single-cell apoptosis (single-cell keratinization), tonofilaments; large central lesions with a tendency to cavitate; parathyroid-hormone- like activity raises serum calcium; men smoking non-filtered cigarettes.

**Answer should be SCC, you probably got oat cell carincoma from a very very old exam!

 

[ibeflossin]

can u guys explain this...


the pulmonary neoplasm to which the endocrine effect of parathyroidism is attributed is
1)adenocarcinoma
2)oat cell carcinoma
3)pheochromocytoma
4)medullary carcinooma
5)squamous cell carcinoma

Ans is 2..i though oat cell carcinoma only produces ADH and ACTH..anyone knows link with parathryorid.

thanks!!

Oat cell simply means "small cell". It is thought to originate from neuroendocrine calls (APUD cells) in the bronchus called Feyrter cells. They express varieties of neuroendocrine marks & may lead to ectopic production of hormones like ADH & ACTH that may result in paraneoplastic syndromes, & SIADH.

Oat cell carcinoma: Kulchitsky (APUD) cell of origin, tiny white, fishflesh primaries near hilum with early and widespread metastases; 15 micron almost-no-cytoplasm cells, paraneoplastic syndromes include, Eaton-Lambert, inappropriate ADH, Cushingism from ACTH, more; not hypercalcemia. Bombesin's the autocrine growth factor. Remember secondary hyperparathyroidism is commonly caused by hypercalcemia!

Squamous cell carcinoma: Keratin pearls, bridges (prickles, desmosomes), single-cell apoptosis (single-cell keratinization), tonofilaments; large central lesions with a tendency to cavitate; parathyroid-hormone- like activity raises serum calcium; men smoking non-filtered cigarettes.

**Answer should be SCC, you probably got oat cell carincoma from a very very old exam!