NBME 11 q

[Master Deep]

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A 16 yo old boy who freq goes fishing is brought to the dr because of a one month lesion on his shoulder. He has blonde hair and fair skin. Physical exam shows an 0.8 cm ulcerated slightly raised nodule that is variably brown to black. A biopsy specimen of the nodule confirms a superficilaly invasive melanoma with featuers of regression. What explains the lesions regression in this patient?

Antibody dependent cellular rxn
Antibody mediated cellular dysfunx
Arthus rxn
Complement and Fc receptor mediated resposne
T lymphocyte mediated cytotoxicity

 

[Master Deep]

Protection against paralytic polio can be achieved either by oral administration of live attenuated adminsteration of killed poliovirus(salk) vaccine. The common feature of these two vaccines, which which of the following poliovirus sepcific immune responess?

A activated CD8 cytotoxic T lymhocyte effectors in the circulation
B activated CD8 cytotoxic T lymphocyte effectors int he gut
C CD8 memory T lymphocytes
D neuralizating antibodies in the circulation
E neurtralizing secretory IgA antibodies in the gut

 

[Cochan]

A 16 yo old boy who freq goes fishing is brought to the dr because of a one month lesion on his shoulder. He has blonde hair and fair skin. Physical exam shows an 0.8 cm ulcerated slightly raised nodule that is variably brown to black. A biopsy specimen of the nodule confirms a superficilaly invasive melanoma with featuers of regression. What explains the lesions regression in this patient?

Antibody dependent cellular rxn
Antibody mediated cellular dysfunx
Arthus rxn
Complement and Fc receptor mediated resposne
T lymphocyte mediated cytotoxicity

I would consider T lymphocyte mediated cytotoxicity. CD8 cells are responsible for killing neoplasia along with NK cells.

 

[ArcGurren]

1. - E, T cell mediated cytotoxicity, since it's a neoplastic growth you're expecting CTLs to react against it (CD8+)

2. - D, remember that killed vaccines do not induce cell mediated immunity. The oral vaccine is the only one that would induce mucosal immunity (IgA) since it comes into contact with the gut, and also because it's alive/attenuated it would induce cell mediated immunity (lymphocytes). The only thing it shares with the killed vaccine is that it would induce circulating antibodies. A, B, C, and E are eliminated if you know the difference between killed and live vaccines.

 

[LuckiestOne]

A 16 yo old boy who freq goes fishing is brought to the dr because of a one month lesion on his shoulder. He has blonde hair and fair skin. Physical exam shows an 0.8 cm ulcerated slightly raised nodule that is variably brown to black. A biopsy specimen of the nodule confirms a superficilaly invasive melanoma with featuers of regression. What explains the lesions regression in this patient?

Antibody dependent cellular rxn
Antibody mediated cellular dysfunx
Arthus rxn
Complement and Fc receptor mediated resposne
T lymphocyte mediated cytotoxicity

Reviving this thread, so why can't it be Antibody dependent cellular reaction? Isn't NK cell more known for killing cancer cells than Cytotoxic T cells?

I would think NK cells have bigger influence just in case the cancer cells do not express sufficiently different MHC... What do you guys think?

 

[pmat]

The following step in the process is the invasive melanoma — the vertical growth phase (VGP). The tumor attains invasive potential, meaning it can grow into the surrounding tissue and can spread around the body through blood or lymph vessels. The tumor thickness is usually more than 1 mm (0.04 in), and the tumor involves the deeper parts of the dermis.

The host elicits an immunological reaction against the tumor (during the VGP),[22] which is judged by the presence and activity of the tumor infiltrating lymphocytes(TILs). These cells sometimes completely destroy the primary tumor; this is called regression, which is the latest stage of the melanoma development. In certain cases, the primary tumor is completely destroyed and only the metastatic tumor is discovered. About 40% of human melanomas contain activating mutations affecting the structure of the B-Raf protein, resulting in constitutive signaling through the Raf to MAP kinase pathway.