NBME 12: Nuclear vs Cytosolic Receptor - NBME or FA Wrong?

[cameraGEEK]

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NBME 12, Block 3, Number 12 - essentially asks is the cortisol (dexamethasone) receptor located in the cell. I was tempted to pick "nuclear receptor", but FA (pg 294) emphasized that it cortisol has a cytosolic receptor, and only T3/T4 has an actual nuclear receptor. I now see that most people think the answer is nuclear receptor - is First Aid wrong?

 

[tootheye]

Cortisol is a cytoplasmic receptor, how ever the transcription for the production takes place in the nucleus explaining the delay for its release. Thyroid is a nuclear receptor. Other nuclear receptors are for Retinoids, PPAR, Fatty acids ( Not sure if mentioned in FA in Endo section).

 

[Morsetlis]

The GR is in the cytosol. Upon binding to cortisol, it translocates to the nucleus to bind the GRE.