NBME 18 - a couple of questions

[zeevee]

---

Members don't see this ad.

Have a weak concept in this .If someone can explain how to approach these questions that would be awesome

.Got this Q correct because I assumed this to be HSP .
Cannot correlate the cryoglobulins or the liver size though .

Cant see why B cannot be correct ?

 

[dfib slim]

For your second one when you see a patient with a rash and is hep C positive think cryoglobulinemia. Think HSP in kids. Here they even give you that the patient has positive cryoglobulins. It's a vasculitis caused by deposition of IgM against anti-hep C IgG which is answer C. Liver findings just point you toward hepatitis.

Third one can't be B. Statins inhibit HMG-CoA reductase so the cell will try to ramp up transcription of the enzyme to make up for it.

 

[deep582]

Here's a quick diagram to help explain 1, hope it helps
Dfib is right about the other two

 

[zeevee]

Here's a quick diagram to help explain 1, hope it helps
Dfib is right about the other two

@ deep582 thank you for your effort .
So the first segregation occurs in the first spermatocyte when first meiotic div is taking place and that is why and when the extra X chromsome was inherited.
What faults can occur at the second meiotic division ? Are there diseases occurring particulalry at Meiosis II ?

 

[jqueb29]

What faults can occur at the second meiotic division ? Are there diseases occurring particulalry at Meiosis II ?

Prior to the second meiotic division, a normal secondary spermatocyte will contain either two copies of X or two copies of Y. It should divide into 2 spermatids, each with either one X or one Y. Failure of the second meiotic division would result in a spermatid with either two X's or two Y's, so you could end up with XXX or XYY offspring.

 

[zeevee]

🙁.I am back to square one

 

[zeevee]

Prior to the second meiotic division, a normal secondary spermatocyte will contain either two copies of X or two copies of Y. It should divide into 2 spermatids, each with either one X or one Y. Failure of the second meiotic division would result in a spermatid with either two X's or two Y's, so you could end up with XXX or XYY offspring.

thanku it makes clear sense

 

[gabsofabb]

Can someone please explain?
12. 45-year-old man with hypertension not compliant with medications. bp 160/100. Cardiac exam shows apical impulse displaced laterally, loud S2 and S4 gallop. Echo shows thickening of left ventricular wall. Mechanism of change in cardiac muscle?
Answer: Transcription factor c-Jun: increased, beta-myosin heave chain: increased, endothelin: increased

 

[aspiringmd1015]

how did you guys use sketchy micro, did you just listen, or did you use the review option to them

 

[jqueb29]

Can someone please explain?
12. 45-year-old man with hypertension not compliant with medications. bp 160/100. Cardiac exam shows apical impulse displaced laterally, loud S2 and S4 gallop. Echo shows thickening of left ventricular wall. Mechanism of change in cardiac muscle?
Answer: Transcription factor c-Jun: increased, beta-myosin heave chain: increased, endothelin: increased

He has hypertrophic cardiomyopathy, which is associated with mutations in beta-myosin heavy chain.

 

[jqueb29]

how did you guys use sketchy micro, did you just listen, or did you use the review option to them

I did both

 

[gabsofabb]

He has hypertrophic cardiomyopathy, which is associated with mutations in beta-myosin heavy chain.

Thank you!