NBME #2 Discussion Spoiler thread

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Boardz

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1. A 50-year-old man with a 20-year history of type
2 diabetes mellitus has had sensory neuropathy for 2 weeks.
Pulses are decreased at the ankle. There is no peripheral edema. His serum
glucose levels have been between 150 mg/dL and 200 mg/dL over the past 6
months. Which of the following is the most effective measure to prevent
serious foot infections?

A) Use of support hose

B) Use of well-fitted shoes

C) Prophylactic antibiotics

D) Daily aspirin and dipyridamole

E) Decrease in serum glucose level

conflicting answer keys. what do ya'll think?
 
3.) A 5-year-old girl is brought to the physician 30 minutes after
being bitten on the forearm by her cat. Examination shows a small
puncture wound covered with dried blood. She is at increased risk of
infection for which of the following reasons?

A) Arm wounds are more susceptible to infection

B) Salivary enzymes in cats augment infection

C) It is difficult to cleanse pathogens from this wound

D) The Staphylococcus species involved is particularly virulent

E) Young children are less able to resist infection than adults

2 of the answer keys say one thing. And it's wrong. Anyone?
 
5.) A sexually active 20-year-old woman has had fever, chills, malaise, and pain of the
vulva for 2 days. Examination shows a vulvar pustule that has ulcerated and
formed multiple satellite lesions. Nodes are palpated in the inguinal and
femoral areas. A smear of fluid from the lesions establishes the diagnosis.
Which of the following is the most likely causal organism?

A) Chlamydia trachomatis

B) Haemophilus ducreyi

C) Neisseria gonorrhoeae

D) Streptococcus pyogenes (group A)

E) Treponema pallidum

One key says A or B and another says D.
 
oh wait, is this nbme 2 a clinical basic science one or clinical skills one? IS there a cbbsa number 2?
 
Painful lymphadenopathy with Inguinal involvement: Hemophilus Ducreyi; Syphilis is a painless ulcer.

The first one; if i had to guess I'll say lower sugar level.

That's one tough exam though man.
 
Painful lymphadenopathy with Inguinal involvement: Hemophilus Ducreyi; Syphilis is a painless ulcer.

The first one; if i had to guess I'll say lower sugar level.

That's one tough exam though man.

lol those are the first five questions.
 
Painful lymphadenopathy with Inguinal involvement: Hemophilus Ducreyi; Syphilis is a painless ulcer.

The first one; if i had to guess I'll say lower sugar level.

That's one tough exam though man.

Oh, I didn't read the question to say her ulcer was painful.
 
1. A 50-year-old man with a 20-year history of type
2 diabetes mellitus has had sensory neuropathy for 2 weeks.
Pulses are decreased at the ankle. There is no peripheral edema. His serum
glucose levels have been between 150 mg/dL and 200 mg/dL over the past 6
months. Which of the following is the most effective measure to prevent
serious foot infections?

A) Use of support hose

B) Use of well-fitted shoes

C) Prophylactic antibiotics

D) Daily aspirin and dipyridamole

E) Decrease in serum glucose level

conflicting answer keys. what do ya'll think?


I'm between Use of well fitted shoes and decrease serum glucose. I'm leaning towards the shoes because it seems like he's past the point of no return in terms of developing the peripheral neuropathy. Diabetics have to be extremely careful with their feet because the combo of peripheral neuropathy plus decreased perfusion makes them really propense to hurting their feet and having an abscess turn into gangrene in a flash. What was the answer, I didn't do that block yet?
 
Those are the first 5? Not on my version. Q1 Block 1 in the one I have starts with LPS mediated activation of transcription, whats the transcription factor.
 
Those are the first 5? Not on my version. Q1 Block 1 in the one I have starts with LPS mediated activation of transcription, whats the transcription factor.

yeah, i don't know WHAT i had. maybe step 2 stuff or nbme cs or something. but, doing the real thing- I thought it was an OK nbme. I have to look a couple things up.
 
Dude's right pupil is "small." PE shows that the right pupil is constricted and does not react to light. His left pupil is normal. These findings are most likely due to a lesion involving which of the following structures on the right?

a. cervical spinal cord
b. frontal eye fields
c. lateral geniculate nucleus
d. optic tract
e. visual cortex.

could someone explain this to me? Thanks!
 
Which of the following drugs produces vasoconstriction that is not blocked by prazosin and bradycardia that is blocked by scopolamine?

a. amphetamine
b. angiotensin
c. norepinephrine
d. phenylephrine

?
 
Dude's right pupil is "small." PE shows that the right pupil is constricted and does not react to light. His left pupil is normal. These findings are most likely due to a lesion involving which of the following structures on the right?

a. cervical spinal cord
b. frontal eye fields
c. lateral geniculate nucleus
d. optic tract
e. visual cortex.

could someone explain this to me? Thanks!

My answer: A

B, C, D and E all somehow relate to cranial nerve 2 (optic) and vision.

Answer A can relate to cervical sympathetic ganglion, which when compromised causes Horners syndrome. One of the symptoms of horners is miosis.

Dont know if that is correct answer though.

EDIT: Just flipped thru FA on CNs. CN III causes pupillary constriction. CN II is the afferent part of pupillary reflex.
 
Which of the following drugs produces vasoconstriction that is not blocked by prazosin and bradycardia that is blocked by scopolamine?

a. amphetamine
b. angiotensin
c. norepinephrine
d. phenylephrine

?

My answer: B, angiotensin

Angiotensin causes vasoconstriction by AT receptors which are not blocked by selective alpha 1 blocker prazosin.

Angiotensin also causes volume increase in blood and HTN which stimulates baroreceptors to decrease heart rate through increased vagal(parasympathetic) stimulation on heart, which can be blocked by antimuscarinic drugs like scopolamine.
 
I'm between Use of well fitted shoes and decrease serum glucose. I'm leaning towards the shoes because it seems like he's past the point of no return in terms of developing the peripheral neuropathy. Diabetics have to be extremely careful with their feet because the combo of peripheral neuropathy plus decreased perfusion makes them really propense to hurting their feet and having an abscess turn into gangrene in a flash. What was the answer, I didn't do that block yet?

Right but at the same time, the questions ask for preventing serious foot infection.
Shoes will protect against a wound formation, but not subsequent infection of wound.

Low glucose will protect against serious infection (because bacteria love the high glucose in diabetic wounds).

Abx will protect against bacterial infection of a wound to begin with.

Tricky question.

EDIT: I just looked up diabetic foot infections in Davidssons internal medicine book.
On prophylaxis it basically only listed Well fitting shoes from the answer choices above. So it seems well fitting shoes is the answer.
 
Last edited:
Yea I think I got a uworld or kaplan q that was similar. I answered to decrease carbs in diet (lower glucose) and the answer was that the diabetic needed to check his feet daily.

Sent from my PC36100 using SDN Mobile
 
My answer: A

B, C, D and E all somehow relate to cranial nerve 2 (optic) and vision.

Answer A can relate to cervical sympathetic ganglion, which when compromised causes Horners syndrome. One of the symptoms of horners is miosis.

Dont know if that is correct answer though.

EDIT: Just flipped thru FA on CNs. CN III causes pupillary constriction. CN II is the afferent part of pupillary reflex.

This one is really bothering me. Horners gas miosis but the pupils are reactive to light. In both central and cervical horners.

I looked up the question for more clarity and its a healthy 48 year old man who goes to the.doctor because his wife noticed one of his pupils is small and on PE one pupil was fixed and constricted while the other one was normal. I remember seeing this question on a neuro shelf but I never looked up the question.

I know its not LGN or FEF. And I wouldn't think its optic tract lesion, but what if he has a mass that's only impinging one side of the optic tract? Would that cause only one eye to be affected? But then again there was no mention of any visual defect, it seemed like he had a tonic pupil which is apparently common.

Sent from my PC36100 using SDN Mobile
 
This one is really bothering me. Horners gas miosis but the pupils are reactive to light. In both central and cervical horners.

I looked up the question for more clarity and its a healthy 48 year old man who goes to the.doctor because his wife noticed one of his pupils is small and on PE one pupil was fixed and constricted while the other one was normal. I remember seeing this question on a neuro shelf but I never looked up the question.

I know its not LGN or FEF. And I wouldn't think its optic tract lesion, but what if he has a mass that's only impinging one side of the optic tract? Would that cause only one eye to be affected? But then again there was no mention of any visual defect, it seemed like he had a tonic pupil which is apparently common.

Sent from my PC36100 using SDN Mobile

Youre overthinking this one by labeling it as Horners syndrome.

"As CKent advised, turn to lights down low and shine your light down low and shine your pen light. For testing or pimping purposes, if the bigger one reacts, the bigger one is normal and the smaller one is loss of sympathetic. If the bigger one doesn't react, the smaller one is normal and the bigger one is CNIII tone loss." - El guapo

So optic tract is not CN 3 right?

So since this pupil is not reactive to light and is small it means it has lost sympathetic innervation. Cervical spine lesion is the only answer that fits (since the sympathetic innervation goes down to T1 before coming back out to innervate the pupillary muscle).
 
My answer: A

B, C, D and E all somehow relate to cranial nerve 2 (optic) and vision.

Answer A can relate to cervical sympathetic ganglion, which when compromised causes Horners syndrome. One of the symptoms of horners is miosis.

Dont know if that is correct answer though.

EDIT: Just flipped thru FA on CNs. CN III causes pupillary constriction. CN II is the afferent part of pupillary reflex.

Yeah, the answer for one answer sheet online and another that belleza sent to me said the answer was optic tract. ?
 
My answer: B, angiotensin

Angiotensin causes vasoconstriction by AT receptors which are not blocked by selective alpha 1 blocker prazosin.

Angiotensin also causes volume increase in blood and HTN which stimulates baroreceptors to decrease heart rate through increased vagal(parasympathetic) stimulation on heart, which can be blocked by antimuscarinic drugs like scopolamine.

this might be silly, but i didn't knkow angiotensin was a drug.
 
Right but at the same time, the questions ask for preventing serious foot infection.
Shoes will protect against a wound formation, but not subsequent infection of wound.

Low glucose will protect against serious infection (because bacteria love the high glucose in diabetic wounds).

Abx will protect against bacterial infection of a wound to begin with.

Tricky question.

EDIT: I just looked up diabetic foot infections in Davidssons internal medicine book.
On prophylaxis it basically only listed Well fitting shoes from the answer choices above. So it seems well fitting shoes is the answer.

I went with the fitting shoes too but an answer sheet said lower the glucose.
 
3.) A 5-year-old girl is brought to the physician 30 minutes after
being bitten on the forearm by her cat. Examination shows a small
puncture wound covered with dried blood. She is at increased risk of
infection for which of the following reasons?

A) Arm wounds are more susceptible to infection

B) Salivary enzymes in cats augment infection

C) It is difficult to cleanse pathogens from this wound

D) The Staphylococcus species involved is particularly virulent

E) Young children are less able to resist infection than adults

2 of the answer keys say one thing. And it's wrong. Anyone?

this was an awesome question actually- and I think over our heads as early 3rd years. the answer is c. uptodate has an awesome article on animal bites and specifically addresses the difficulties of puncture wounds and how they are treated from other bites.
 
58 y.o. man has blood in urine. He had a nephrectomy 10 years ago b/c of injuries sustained in a motor vehicle collision. Evaluation shows renal cell carcinoma in his remaining kidney and pulmonary metastases. Interleukin-2 therapy is started. Three weeks later, CT scan confirms regression of the tumor. Which of the following most likely caused the regression?

An effect of IL-2 on tumor vascularization
Cytotoxic effects of IL-2 on tumor cells
Increased natural killer cell activity
Induction of antitumor antibodies by IL-2
Induction of B-lymphocyte proliferation
Spontaneous remission

? wtf
 
this might be silly, but i didn't knkow angiotensin was a drug.

That is very silly indeed. None of the other choices work with both effects. if this is in fact the verbatim question then someone at NBME screwed up alittle with the wording.

Angiotensin is the only one that fits with the pharmacophysiology.
 
Why do all the answer sheets have errors?!!! That NBME2 has been around for a decade and somehow we dont have all the correct answers....maybe people stopped paying to take this one 🙂
 
Yeah, the answer for one answer sheet online and another that belleza sent to me said the answer was optic tract. ?

So explain it to me , why is optic tract correct?

Pupillary muscle wikipedia:
"It is controlled by parasympathetic fibers that originate from the Edinger-Westphal nucleus, travel along the oculomotor nerve (CN III), synapse in the ciliary ganglion, and then enter the eye via the short ciliary nerves."

Optic tract wikipedia:
It is a continuation of the optic nerve (CN II) and runs from the optic chiasm (where half of the information from each eye crosses sides, and half stays on the same side) to the lateral geniculate nucleus.


If you lesion CN III you will have mydriasis!!!!!!!!! CN III is NOT optic tract, it is oculomotor nerve. The Edinger-Wetphal nucleus is in the brainstem, the parasympathetic nerves inhibiting miosis travel down and out of the brainstem at T1 and back up again through cervical ganglia. That is why you get miosis if you get a Pancoast tumor on apex of lung or neck stab wound lesioning your cercival ganglion tract!
 
58 y.o. man has blood in urine. He had a nephrectomy 10 years ago b/c of injuries sustained in a motor vehicle collision. Evaluation shows renal cell carcinoma in his remaining kidney and pulmonary metastases. Interleukin-2 therapy is started. Three weeks later, CT scan confirms regression of the tumor. Which of the following most likely caused the regression?

An effect of IL-2 on tumor vascularization
Cytotoxic effects of IL-2 on tumor cells
Increased natural killer cell activity
Induction of antitumor antibodies by IL-2
Induction of B-lymphocyte proliferation
Spontaneous remission

? wtf


My answer: Cytotoxic effect of IL-2 on tumor cells

Hot T Bone stEAk
IL 1 2 3 4 5

Hot: IL 1 - fever
T: IL 2 T cell activator
Bone: IL 3 B cell proliferator
stE: IL 4 IgE class switching
Ak: IL 5 IgA class switching

Cytotoxic T cell activation and subsequent CD 8 T cell phagocytosis of tumor cells.
 
Well I have the fitting shoes answer confirmed in http://www.amazon.com/Davidsons-Pri...&sr=8-1&keywords=Davidssons+internal+medicine

So unless your answer key was provided by NBME I would take the answer keys answers with a big grain of salt.

Uptodate: Patient information: Foot care in diabetes mellitus (Beyond the Basics) PREVENTING FOOT PROBLEMS IN DIABETES — Controlling blood sugar levels can reduce the blood vessel and nerve damage that often lead to diabetic foot complications. If a foot wound or ulcer does occur, blood sugar control reduces the risk of requiring amputation. (See "Patient information: Self-blood glucose monitoring in diabetes mellitus (Beyond the Basics)".)

Foot care is important, although patients should also continue to follow other general guidelines for managing diabetes.

The following strategies can reduce the chances of developing foot problems.

Quit smoking — Smoking can worsen heart and vascular problems and reduce circulation to the feet. (See "Patient information: Quitting smoking (Beyond the Basics)".)

Avoid activities that can injure the feet — Some activities increase the risk of foot injury and are not recommended, including walking barefoot, using a heating pad or hot water bottle on the feet, and stepping into the bathtub before testing the temperature.

Use care when trimming the nails — Trim the toe nails along the shape of the toe and file the nails to remove any sharp edges (figure 1). Never cut (or allow a manicurist to cut) the cuticles. Do not open blisters, try to free ingrown toenails, or otherwise break the skin on the feet. See a healthcare provider or podiatrist for even minor procedures.

Wash and check the feet daily — Use lukewarm water and mild soap to clean the feet. Gently pat your feet dry and apply a moisturizing cream or lotion.

Check the entire surface of both feet for skin breaks, blisters, swelling, or redness, including between and underneath the toes where damage may be hidden. Use a mirror if it is difficult to see all parts of the feet or ask a family member or caregiver to help.

Choose socks and shoes carefully — Select cotton socks that fit loosely, and change the socks every day. Select shoes that are snug but not tight, and break new shoes in slowly to prevent any blisters (figure 2). Ask about customized shoes if the feet are misshapen or have ulcers; specialized shoes can reduce the chances of developing foot ulcers in the future. Shoe inserts may also help cushion the step and decrease pressure on the soles of the feet.

Ask for foot exams — Screening for foot complications should be a routine part of most medical visits, but is sometimes overlooked. Don't hesitate to ask the healthcare provider for a foot check at least once a year, and more frequently if there are foot changes.

Uptodate: Evaluation of the Diabetic Foot
Preventive foot care — In conjunction with screening, counseling regarding preventive foot care should be given to any patient whose feet are at risk. (See "Patient information: Foot care in diabetes mellitus (Beyond the Basics)".) There are a series of recommendations that can markedly diminish ulcer formation; they are particularly important in patients with existing neuropathy.

Avoid smoking, walking barefoot, the use of heating pads or hot water bottles, and stepping into a bath without checking the temperature.
The toenails should be trimmed to the shape of the toe and filed to remove sharp edges.
The feet should be inspected daily, looking between and underneath the toes and at pressure areas for skin breaks, blisters, swelling, or redness. The patient may need to use a mirror or, if vision is impaired, have someone else perform the examination.
The patient's shoes should fit properly and not be too tight, and the socks should be cotton, loose fitting, and changed every day. Patients who have misshapen feet or have had a previous foot ulcer may benefit from the use of special customized shoes. A prospective study found that shoe variables other than the recommendation for customized shoes (eg, style, width, length, or type of shoe) had no preventive effect [31]. The use of customized shoes, however, reduced the development of new foot ulcers from 58 to 28 percent over one year of follow-up in a second report [32]. In a third review, the use of a viscoelastic insole in conjunction with well-fitting shoes (whether customized, standard "comfort" or athletic shoes) was associated with a decrease in plantar pressure; whether this results in a reduced incidence of foot ulcers remains to be determined [33].
The feet should be washed daily in lukewarm water. Mild soap should be used and the feet should be dried by gentle patting. A moisturizing cream or lotion should then be applied.
A particularly effective strategy is to make specific recommendations to the patient in the form of a "contract" and to advise the patient to request that his or her feet be examined at every visit to the doctor or nurse [34].

In addition to the foot care measures described above, preliminary data suggest that home temperature monitoring may be effective in preventing foot ulceration in very high risk patients (for example, those with severe neuropathy and a history of prior amputations or ulcers) [35,36]. Temperature monitoring involves daily or twice daily measurements of skin surface temperature with a thermometer equipped with a touch sensor. If a temperature difference (elevation) is detected between a right and left foot site (figure 1), patients are instructed to reduce activity until the temperature normalizes. Whether the benefit of monitoring temperature is specifically related to the monitoring, or the heightened attention to foot care in those performing the monitoring, is not clear. Additional efficacy and feasibility studies are required before home temperature monitoring can be recommended to reduce the risk of foot ulcers.

Cool. just fyi.
 
My answer: Cytotoxic effect of IL-2 on tumor cells

Hot T Bone stEAk
IL 1 2 3 4 5

Hot: IL 1 - fever
T: IL 2 T cell activator
Bone: IL 3 B cell proliferator
stE: IL 4 IgE class switching
Ak: IL 5 IgA class switching

Cytotoxic T cell activation and subsequent CD 8 T cell phagocytosis of tumor cells.

The answer was Increased Natural killer cell activity. I don't think "cytotoxic effects of IL-2 on tumor cells" is correct because IL-2 doesn't have direct cytotoxic activity. You're totally right that it induces cytotoxic T-cell cytotoxic action, but I think the answer implied direct cytotoxic effect. Am I wrong here? Idk, that's why I posted it because I was confused.

"increased natural killer cell activity" works because:
1) first aid: "Natural killer cells Use perforin and granzymes to induce apoptosis of virally infected cells and tumor cells." ... "acitivity enhanced by IFN-alpha, IFN-beta, IL-12."

2) IL-2 activates and induces proliferation of natural killer cells

Wiki: Natural Killer Cell
"Cytokines involved in NK activation include IL-12, IL-15, IL-18, IL-2, and CCL5."

Wiki: Interleukin-2
"IL-2 has been found to be similar to IL-15 in terms of function.[18] Both cytokines are able to facilitate production of immunoglobulins made by B cells and induce the differentiation and proliferation of natural killer cells."

Uptodate: NK cell deficiency syndromes: Treatment
"Interleukin-2 — One biologic agent that is capable of increasing NK cell activities is interleukin-2 (IL-2) [2]. IL-2 has been used in individuals with malignancy and HIV infection and has been shown to increase NK cell activity. It has also been reported to have clinical benefit or increase NK cell activity in diseases having impaired NK cell function [3,4]."

Uptodate actually has IL-2 stimulating NK cells all over the place in many entries.

googling:
1st hit) Nature article "Interleukin-2 augments natural killer cell activity"
2nd) Natural killer cells activated by IL-2...
3) Interleukin-2 activation of natural killer cells rapidly induces...

etc.
But, IL-2 activating Natural killer cells isn't in first aid. :I
 
The answer was Increased Natural killer cell activity. I don't think "cytotoxic effects of IL-2 on tumor cells" is correct because IL-2 doesn't have direct cytotoxic activity. You're totally right that it induces cytotoxic T-cell cytotoxic action, but I think the answer implied direct cytotoxic effect. Am I wrong here? Idk, that's why I posted it because I was confused.

"increased natural killer cell activity" works because:
1) first aid: "Natural killer cells Use perforin and granzymes to induce apoptosis of virally infected cells and tumor cells." ... "acitivity enhanced by IFN-alpha, IFN-beta, IL-12."

2) IL-2 activates and induces proliferation of natural killer cells

Wiki: Natural Killer Cell
"Cytokines involved in NK activation include IL-12, IL-15, IL-18, IL-2, and CCL5."

Wiki: Interleukin-2
"IL-2 has been found to be similar to IL-15 in terms of function.[18] Both cytokines are able to facilitate production of immunoglobulins made by B cells and induce the differentiation and proliferation of natural killer cells."

Uptodate: NK cell deficiency syndromes: Treatment
"Interleukin-2 — One biologic agent that is capable of increasing NK cell activities is interleukin-2 (IL-2) [2]. IL-2 has been used in individuals with malignancy and HIV infection and has been shown to increase NK cell activity. It has also been reported to have clinical benefit or increase NK cell activity in diseases having impaired NK cell function [3,4]."

Uptodate actually has IL-2 stimulating NK cells all over the place in many entries.

googling:
1st hit) Nature article "Interleukin-2 augments natural killer cell activity"
2nd) Natural killer cells activated by IL-2...
3) Interleukin-2 activation of natural killer cells rapidly induces...

etc.
But, IL-2 activating Natural killer cells isn't in first aid. :I

So this is one of those tricky 50/50 questions.
The answer choice doesnt say DIRECT cytotoxic effect on tumor cells, it just says cytotoxic effect on tumor cells. Since it induces both T cells and NK cells according to all the drugs mechanism of action websites I can pull up on Proleukin (IL-2 given as therapy) its a tough choice to make. Yours does seem to fit better in that its more specific, but my answer choice is vaguer but more all encompassing in its cascade of effects.

So, do they want you to do an obscure one step reasoning and think its NK cells activation or do they want you to do multistep thinking of IL-2s cascade effect on the immune system that results in cytotoxicity.

Tough one.
 
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