nbme 5 spoiler!

[topscorer]

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this q was discussed here , but i posted here again cus it deosnt have spoiler alert
http://forums.studentdoctor.net/showthread.php?t=635039

basically when is g versus host disease beneficial

i get how with donor healthy tcells, u can go thru leukemia pt n kill bad wbc's. fine.

what got me lost on this question

was every option had some sorta bad cell, like all, and the rest were autoimmune i guess, so that should of gave it away i suppose. but in sle and those other diseases, where body's attacking itself, wouldnt donor tcells killing of these cells help too??

but i was under the impression, when u give donor TCELL. it goes around killing whatever it doesnt recoginize.

ya sure it'd kill leukemia cells, but doenst it like kill the whole host cus it attacks ALL of the cells right. like muscle and everything. its not like tcells act in blood cells only no?

am i completely off here?

 

[Sol Rosenberg]

They wouldn't kill EVERYTHING, because, even with allografts (assume matched) MOST of the self-antigens would be the same from person-to-person, and most of the graft T-cells would be desensitized to those cells. That's why, in GVHD, it's only certain tissues that seem to be predominantly targeted (biliary tree, skin, GI)

I don't have a lot of time to type out a detailed response, but Graft-vs-Leukemia is kind of a "big idea" from immumology, and anytime you see something talking about beneficial effects from GVHD, think GVL.