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These are a few questions I had regarding NBME 12 that I could not find sufficient answers for in the previous forum for that exam on SDN. If anyone can provide helpful feedback to me regarding the right answer to these, I would be extremely grateful! I will paraphrase the questions as appropriate.
1) During an experiment of the effects of renal ATP function, a kidney is excised and perfused with a mitochondrial inhibitor. In which of the following nephron segments is the greatest decrease in resorption most likely?
a) collecting duct
b) DCT
c) PCT
d) Thick ascending limb of Henle's loop
e) Thin ascending limb of Henle's loop
f) Thin descending limb of Henle's loop
I chose D, which is incorrect, based on the fact that juxtamedullary regions of the straight convoluted tubule and the thick ascending limb are most susceptible to ischemic tubular necrosis. Is C therefore the correct answer?
2) A 3 day old female newborn is brought to the physician because of yellow eyes for 1 day. The newborn was delivered at term after an uncomplicated pregnancy. The newborn and her mother are both blood group A, Rh-positive. Physical exam shows scleral and factial icterus. Her serum total bilirubin is 6mg/dL, with a direct component of 0.5 mg/dL. Serum AST and ALT activities are within normal. A direct Coombs result is negative. Which of the following is the most likely cause of jaundice in the newborn?
A) Biliary atresia
B) G1P uridylytransferase deficiency
C) G6Pase deficiency
D) Immune hemolysis (wrong... I don't know why I chose that... all signs said it's not this... but I wasn't sure what else lead to indirect hyperbilirubinema)
E) UDP glucuronsyltransferase deficiency
F) Viral hepatitis
I chose A which is incorrect, but I'm not sure I understand why. I believe E is the correct choice for neonatal jaundice, but do you rule A out because of the normal AST and ALT?
1) During an experiment of the effects of renal ATP function, a kidney is excised and perfused with a mitochondrial inhibitor. In which of the following nephron segments is the greatest decrease in resorption most likely?
a) collecting duct
b) DCT
c) PCT
d) Thick ascending limb of Henle's loop
e) Thin ascending limb of Henle's loop
f) Thin descending limb of Henle's loop
I chose D, which is incorrect, based on the fact that juxtamedullary regions of the straight convoluted tubule and the thick ascending limb are most susceptible to ischemic tubular necrosis. Is C therefore the correct answer?
2) A 3 day old female newborn is brought to the physician because of yellow eyes for 1 day. The newborn was delivered at term after an uncomplicated pregnancy. The newborn and her mother are both blood group A, Rh-positive. Physical exam shows scleral and factial icterus. Her serum total bilirubin is 6mg/dL, with a direct component of 0.5 mg/dL. Serum AST and ALT activities are within normal. A direct Coombs result is negative. Which of the following is the most likely cause of jaundice in the newborn?
A) Biliary atresia
B) G1P uridylytransferase deficiency
C) G6Pase deficiency
D) Immune hemolysis (wrong... I don't know why I chose that... all signs said it's not this... but I wasn't sure what else lead to indirect hyperbilirubinema)
E) UDP glucuronsyltransferase deficiency
F) Viral hepatitis
I chose A which is incorrect, but I'm not sure I understand why. I believe E is the correct choice for neonatal jaundice, but do you rule A out because of the normal AST and ALT?