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In an action potential, sodium ions (Na+) are primarily responsible for the depolarization phase**, while potassium ions (K+) are responsible for the repolarization phase.
Depolarization: The initial phase of an action potential, characterized by the membrane potential becoming more positive, is largely due to the influx (movement into the cell) of sodium ions through voltage-gated sodium channels.
Cardiac electrophysiology: Action potential, automaticity ...
Repolarization: The subsequent return of the membrane potential to its resting state (a negative value) involves the outflow (movement out of the cell) of potassium ions through voltage-gated potassium channels.
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