non-Hodgkin lymphoma

[MudPhud20XX]

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Can anyone explain why you have an increased risk for non-Hodgkin lymphoma in both common variable immunodeficiency (CVI) and in Sjogren syndrome?

Also, any particular reason you get Giardia lamblia (among many) infection in CVI?

Many thanks in advance.

 

[orangejello]

decreased immunosurveillance => more cancer is a general theme you'll see throughout pathology

CVI and sjogrens are indicative of B cell defect... further accumulation of defects eventually leads to cancer

decreased gut IgA is why giardia runs wild in CVI