I apologize for not making myself completely clear. Isolated in that the school is in itself a little community, with a whole complex that houses all the buildings, separated form the rest of the area by walls. And the surrounded areas are mostly residential and a few stores. You are correct that NYC is 40 min away. I am fully aware of this as I had to fly into JFK, take subway, transfer to the train to get there. So yes, NYC is close by. Milwaukee is actually a big city itself, so Chicago is only an additional destination to go to. I am from the West Coast, so the reputation in the West Coast at least is that MCW is better and several of the post-docs in my lab has heard of it (they are outside the medical community, i give you that much) and know about their reputation at least in the research realm. I am only offering my opinion, no need to take all my words literally. Either school, you will come out with a MD. Its just a matter of WHERE you want to spend the next four years, and what your career goals are. As long as you stay true to yourself and work hard, it doesn't matter which school has better reputation or what other think of the school. I have this same decision to make on whether to go to MCW or NYMC. And I have chosen MCW. Good luck on the OP's choice.