Ochem Destroyer #56 (2011) question

[KyoPhan]

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I narrowed it down to B and C. From chad's video, I believed he said something along the lines of the ortho has 2 locations where it can attach, but the para is good as well as it is less sterically hindered. I believe he concluded by saying we cannot say which is major.

Am I missing some information or did I misinterpret what he said? Is there any case where the ortho would be better?

 

[BullsDMD]

Para is usually preferred over ortho bc of steric hindrance I think. Makes sense, the cl is a big atom and wouldn't want to be put in that corner, it would spread itself out. I think you would do ortho if para was taken or there were multiple activating/deactivating molecules

 

[pfg459]

I narrowed it down to B and C. From chad's video, I believed he said something along the lines of the ortho has 2 locations where it can attach, but the para is good as well as it is less sterically hindered. I believe he concluded by saying we cannot say which is major.

Am I missing some information or did I misinterpret what he said? Is there any case where the ortho would be better?

Yes, the N group is directing it to the ortho para position, but para is the major product in this case.