Yeah seconding/thirding above, though maybe PI is the wrong lingo here. Either way, you need faculty support unless you've already been publishing these kind of studies on your own in major journals. This field -- especially research -- is all about mentorship. Yes, you can plod through on your own, but I promise you you'll regret it because you'll make little mistakes along the way you don't even realize you're making until it's too late. Your project may even be fundamentally flawed from the start. A good mentor can help you with this.
If it's purely sys review/meta analysis then you won't need IRB approval, but if you're using any medical records or basically anything with real patients then you'll need IRB approval and they will want a PI listed for the study. At my institution, students can be PIs (I have two active ones right now) but you have to have a senior faculty mentor listed as well who will vouch for you and your work. Not sure on the details of your project, but if it ventures into IRB territory you'll definitely need a mentor then too.
Also, don't overlook the networking power of this process. IF this is in a field you're interested in, doing papers with senior faculty early on is a great way to get glowing letters of rec as they will have the chance to know you beyond a few brief encounters during 3rd/4th year.
Also, having the name of a bigwig or two on the paper is HUGE for the overall credibility and reception of the work.