Oncogenes

[gatsbyjo]

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can anybody briefly explain the mechanism(s) by which proto-oncogenes become oncogenes? I understand that several types of mutations (amplification, point, translocation) cause this, but how/why?

 

[omarsaleh66]

can anybody briefly explain the mechanism(s) by which proto-oncogenes become oncogenes? I understand that several types of mutations (amplification, point, translocation) cause this, but how/why?

Normally, proto-oncogenes are normal contributors to the cell cycle, and do not cause any harm. Ok each proto-oncogene has 2 alleles. i think that if u have a point mutation, or some kind of chromosomal translocation, deletion that causes 1 of these alleles to get screwed up, that causes a protoncogene to become an oncogene. Then thats going to lead to alot of proliferation where the cells start growing without any control that will lead to a tumor. Someone please correct me if I'm wrong

peace

 

[lattimer13]

from webpath...

http://medstat.med.utah.edu/WebPath/NEOHTML/NEOPL067.html

 

[Mumpu]

You gots 'dem genes that are normally active and stop cell proliferation and 'dem genes that are normally inactive and start cell proliferation. Messing with either produces badness.

 

[felipe5]

yuppers.......many protooncogenes encode players involved in signal transduction, so any mutation in these genes will have not-so-good manifestations amplified throughout various pathways. Physical manifestations can be seen in the karyotype, including crazy heterogenously staining regions of chromosomes and even double minute chrom's

 

[gatsbyjo]

alright you guys rock. that prevented me from having to google it.... and i got to spend more "special time" in my happy biochem studying