organic nitrates for angina? Help?

[olmaygti]

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can anyone explain me how I.V. Nitroglycerine avoids tachycardia in the treatment of angina which is usually countered in other routes like sub-lingual???

 

[olmaygti]

is it because onset of action through I.V. is the slowest or what?

 

[ArkansasHogMD]

is it because onset of action through I.V. is the slowest or what?

I believe the mechanism of nitro is venodilation more so than arterial vasodilation at low doses. As the dose increases it causes arterial vasodilation resulting in reflex tachycardia. This tachycardia can be offset by using a beta blocker. I also think that the main purpose of nitro is to decrease venous return to the heart which leads to less preload and if you recall the frank starling curve, less stretch and contractility decreasing myocardial demand.

 

[gutonc]

SDN is not the appropriate place to solicit homework help. Closing.