Prepharm was a LOT harder for me. ( granted i have only done one year of pharmacy school thus far). i got 4.0s both semesters of pharm school, and went out a lot more, skipped classes, and studied a/b the same as i did in prepharm.
However, i dont know if it is maybe just because i got usedto/ got better at studying by my 3rd year of school.