Hey,
I was hoping someone could explain the role of acetazolamide on the macula densa. This was a past NBME question (don't remember which #) where acetazolamide works PASSED the macula densa causing osmotic diuresis and INCREASING NaCl delivery to the macula --> afferent a. vasoconstriction. All the others decrease NaCl.
Could someone please explain this to me? How does acetazolamide, a diruetic that works on the PCT, cause increased delivery to the macula? Also, how do other diuretics like furosemide, cause decrease delivery?
I was hoping someone could explain the role of acetazolamide on the macula densa. This was a past NBME question (don't remember which #) where acetazolamide works PASSED the macula densa causing osmotic diuresis and INCREASING NaCl delivery to the macula --> afferent a. vasoconstriction. All the others decrease NaCl.
Could someone please explain this to me? How does acetazolamide, a diruetic that works on the PCT, cause increased delivery to the macula? Also, how do other diuretics like furosemide, cause decrease delivery?