PPIs and applesauce

[pharmacology888]

When patients want to sprinkle the contents of their PPI, the manufacturers usually recommend applesauce. Is this because PPIs are enteric coated and therefore will be released in a relatively alkaline environment, (intestines not stomach) and applesauce/juice is also acidic so the formulation of the PPI would still be intact? Then why is it that some say it's also ok to sprinkle it in milk (which is more alkaline)? Wouldn't this affect the formulation?
Lastly, if PPI's are activated in an acidic environment after absorption in the intestines, wouldn't Zegerid's sodium bicarb component affect the effectiveness of it's PPI component?
thanks

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[MountainPharmD]

Applesauce is a convenient vehicle that does not need to be heated or chewed is my guess.

Zegrid is a joke. From http://www.zegerid.com/:

Immediate-Release or Delayed-Release Acid Reflux Medicines
Except for ZEGERID, all proton pump inhibitors are delayed-release acid reflux drugs. Delayed-release proton pump inhibitors use a coating, called an enteric coating, to protect the acid reflux medicine from acid degradation while passing through the stomach. This coating delays the acid reflux medicine from getting into the bloodstream.
ZEGERID does not have an enteric coating and the acid reflux medicine is rapidly absorbed into the bloodstream. That's why ZEGERID is the First and Only Immediate-Release Oral Proton Pump Inhibitor.

Big whoop de do da. Also from www.zegrid.com which I think says it all:

The correlation of pharmacodynamic data to clinical effect has not been established.

So you take omeprazole, which is very inexpensive and available over the counter, and couple it with sodium bicard an antacid. You call it Zegrid, the combination of two very cheap medications available OTC, and charge $220.00 for a bottle of 30. Genius? I think not.

 

[Priapism321]

Applesauce is a convenient vehicle that does not need to be heated or chewed is my guess.

Zegrid is a joke. From http://www.zegerid.com/:




Big whoop de do da. Also from www.zegrid.com which I think says it all:



So you take omeprazole, which is very inexpensive and available over the counter, and couple it with sodium bicard an antacid. You call it Zegrid, the combination of two very cheap medications available OTC, and charge $220.00 for a bottle of 30. Genius? I think not.

A-effing-men to you brother...

 

[WVUPharm2007]

Genius? I think not.

It is if you get away with it.

 

[DrugDealer]

It is if you get away with it.

I read Zegerid is going OTC later this year.....

And to the OP: I agree with the info from the Zegerid website, the bicarb is to protect the PPI from degradation in the tummy. That's why when you compound omeprazole solution for infants you dissolve the capsule components in a bicarb solution.