Although I think it is generally safer to take prereqs at a four year university, my counselor told me that as long as you don't take "core" classes (so basically chem, bio) at cc that it would be ok. I took calc at a community college too because it is known for being an impossible class at my university and I want that smaller classroom setting to take it in. I know that at my school we have a bunch of GPA's: classes on campus, total GPA including transferred courses, and a major GPA. Also optomcas recalculates your GPA in various categories...so I'll bet anything that those classes will be included in those calculations. If you just google "optomcas GPA calculation" it shows how the calculate your GPA and what the categories are.