Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms

[TheLoneWolf]

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Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts - European Journal of Epidemiology

The potential etiological role of early acetaminophen exposure on Autism Spectrum Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We aimed to study this association in a collaborative study of six European population-based birth/child cohorts. A total of...

link.springer.com

I wonder if this will change practice or more of the same as with the epidural- autism paper.

 

[deleted697535]

Looks like everything causes autism these days

 

[Mman]

I am more willing to believe a drug taken perhaps hundreds of times during pregnancy, especially during 1st trimester when the brain is forming, could have a link with autism than I am willing to believe a few hours of a labor epidural could do it.

That does not mean I think tylenol is causing autism. I mean for all I know moms that get really sick during pregnancy and need to take tylenol are having some impact from their illness/fever that is harming the developing fetal brain.

 

[dhb]

Looks like everything causes autism these days

Everyone and their mother...

X= Autisme
Y= Mental ******ation

 

[GassYous]

I think being autistic causes autism

 

[Guillemot]

Perhaps it's not the Tylenol its self, but the water used to swallow the pills.

 

[deleted162650]

Well sh**. I guess I better stop giving epidural Tylenol.

 

[TheLoneWolf]

Well sh**. I guess I better stop giving epidural Tylenol.

I would bet in the next 10 years, someone will make their academic career publishing epidural or spinal ofirmev use. It came to them after literature review in an attempt to curtail local anesthetic use causing autism and neuraxial opioids as contributors to the opioid epidemic or somesuch issue. I guess only you, I and the SDN crew will know it came from an offhand remark from a PP guy.

 

[deleted162650]

I guess only you, I and the SDN crew will know it came from an offhand remark from a PP guy.

They better cite my ass.

 

[TheLoneWolf]

They better cite my ass.

They will probably link your twitter feed and a prominent cover of your SDN pic.....for science

 

[deleted162650]

They will probably link your twitter feed and a prominent cover of your SDN pic.....for science

On 2nd thought never mind. I don’t want to get sued by Pacira.

 

[HalO'Thane]

"Children prenatally exposed to acetaminophen were overall more likely to have older and non-nulliparous mothers with higher education levels and higher pre-pregnancy BMI who report alcohol consumption, smoking and mental health problems during pregnancy (Table S4). Children postnatally exposed to acetaminophen were more likely to have nulliparous mothers, who have higher education levels and report alcohol consumptions during pregnancy (Table S5)."

Is it just me or did alcohol consumption during pregnancy seem to be a common link with developing autism in this study? I would be more concerned with what underlying medical conditions caused the mothers to take Tylenol rather than just the Tyelonol use itself.

I agree, just like the neonatal anesthetic exposure and neurotoxicity studies going around I wonder how many people will stake their careers on tylenol use and autism development in the future now.

 

[TheLoneWolf]

"Children prenatally exposed to acetaminophen were overall more likely to have older and non-nulliparous mothers with higher education levels and higher pre-pregnancy BMI who report alcohol consumption, smoking and mental health problems during pregnancy (Table S4). Children postnatally exposed to acetaminophen were more likely to have nulliparous mothers, who have higher education levels and report alcohol consumptions during pregnancy (Table S5)."

Is it just me or did alcohol consumption during pregnancy seem to be a common link with developing autism in this study? I would be more concerned with what underlying medical conditions caused the mothers to take Tylenol rather than just the Tyelonol use itself.

I agree, just like the neonatal anesthetic exposure and neurotoxicity studies going around I wonder how many people will stake their careers on tylenol use and autism development in the future now.

That is a good point, I do not see fetal alcohol syndrome (FAS) diagnosed very much, autism spectrum disorder diagnoses have gone up over time largely to diagnostic criteria though I do often wonder if FAS may be misdiagnosed or easily lumped into autism spectrum disorder given the high rates of alcohol consumption. One carries a stigma and causal relation and the other does not. That is not a question I cant answer but would like to hear the opinions of peds anesthesia and pediatricians on the subject.