pristiq absorption

[michaelrack]

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An NP I collaborate with asked me today about a patient of hers taking pristiq. This patient reports pristiq capsules with medication/powder still in it in her stool.
NOT just "ghost capsules"
any one have any experience with this

 

[wolfvgang22]

Yes. I had a patient say the same thing. She has IBS. I changed her to venlafaxine ER and the problem resolved.

 

[Sushirolls]

I've gone liquid formulation of some meds for gastric bypass folks.

 

[michaelrack]

Thanks, trying effexor xr or liquid formulation SSRI is helpful advice

 

[Stagg737]

Wtf, never heard of this but will definitely keep in mind. Has anyone encountered this with any other psych meds? Would like to know since I see a fair number of people with h/o bariatric surgeries and GI issues.

 

[Sushirolls]

Yep. I've my small sample size maybe 5-20%? But it really is hit or miss. One med for one person goes just fine, but not another. It truly is just trouble shooting, trial and error. If starting fresh I try to pick meds I know that also have liquid formulations so we don't have to lose time in a bigger med change up.

 

[aim-agm]

Wtf, never heard of this but will definitely keep in mind. Has anyone encountered this with any other psych meds? Would like to know since I see a fair number of people with h/o bariatric surgeries and GI issues.

IIRC, it's unpredictable and for the first year may keep changing but absorption will usually be consistent past then. The major exception is Lithium, which will be variable well beyond that (permanently?)